Regulatory T Cells Overview | Thermo Fisher Scientific - US
Regulatory T cells (Treg) are critical to the maintenance of self-tolerance and immune cell homeostasis, which is demonstrated by the severe consequences of a lost or nonfunctional Treg population, as occurs in immune dysregulation polyendocrinopathy enteropathy X-linked syndrome (IPEX).
Identification of a CD4 + T cell line with Treg-like activity
Regulatory T cells (Tregs) suppress adaptive immunity and inflammation. Although they play a role in suppressing anti-tumor responses, development of therapeutics that target Tregs is limited by their low abundance, heterogeneity, and lack of specific cell surface markers.
Characterization of MT-2 cells as a human regulatory T cell-like cell line
2014年12月29日 · In this study, we examined the Treg phenotype and the immune suppressive effect of a human T-cell leukemia virus type 1 (HTLV-1) infected cell line, MT-2. The results clearly demonstrated...
Characterization of MT-2 cells as a human regulatory T cell-like cell line
In this study, we examined the Treg phenotype and the immune suppressive effect of a human T-cell leukemia virus type 1 (HTLV-1) infected cell line, MT-2. The results clearly demonstrated that the MT-2 cell line has the phenotypic and functional characteristics of human Tregs and is a useful tool in the study of human Tregs.
Regulation of Treg cells by cytokine signaling and co-stimulatory ...
CD4+CD25+Foxp3+ regulatory T cells (Tregs), a vital component of the immune system, are responsible for maintaining immune homeostasis and preventing excessive immune responses. This review explores the signaling pathways of the cytokines that ...
Diversity and function of regulatory T cells in health and …
Regulatory T cell (Treg) originate from the thymus and migrate to peripheral sites to maintain immune self-tolerance and modulate inflammation. ... Methotrexate (MTX), a standard first-line treatment for RA, acts not only as an anti-folate agent but also significantly downregulates the TP63 gene. TAp63, a subtype of TP63, is expressed at higher ...
Identification of a CD4 + T cell line with Treg-like activity - PubMed
Because it is not possible to functionally characterize cells after intracellular Foxp3 staining, we identified a human T cell line, MoT, as a model of human Foxp3 + Tregs. Unlike Jurkat T cells, MoT cells share common surface markers consistent with human PBMC-derived Tregs such as: CD4, CD25, GITR, LAG-3, PD-L1, CCR4.
Heterochromatic gene silencing controls CD4 + T cell ... - Nature
2025年1月10日 · Treg poorly control allogeneic responses mediated by HP1α-deficient T cells. To identify the molecular events that control the crosstalk between conventional (Tconv) and regulatory CD4 + T cells ...
How regulatory T cells work | Nature Reviews Immunology
Regulatory T (T Reg) cells are essential for maintaining peripheral tolerance, preventing autoimmunity and limiting chronic inflammatory diseases. However, they also limit beneficial...
Characterization of the MT‐2 Treg‐like cell line in the presence …
2024年1月30日 · MT-2 cells, an immortalized Treg-like cell line, offer a model to study Treg biology and their therapeutic potential.
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