2019年11月22日 · These cells had turned on the NLRP3 inflammasome, as seen by the release of ASC specks and the proinflammatory cytokine IL-1β, and they were adjacent to tau tangles. Did this make tau pathology worse? Yes, Ising found. When the authors bred Tau22 mice with NLRP3 knockouts, the crosses accumulated only half as much hyperphosphorylated and ...

2024年1月17日 · P-tau/tau ratios demonstrate that most of the CSF tau-phosphorylated sites (111, 153, 181, 205, 208, 217, and 231) are abnormally hyperphosphorylated in response to amyloid pathology (Barthelemy et al., 2019; Barthelemy et al., 2022; Barthelemy et al., 2020). Thus, in AD, concentrations of these p-tau species in CSF increase more than does t-tau.

2024年3月1日 · Plasma NTA-tau seems to specifically reflect tangles associated with AD. It only increased in people who tested positive for amyloid and for tangles, but not in people who had only tangles (image below). Plasma NTA-tau more accurately correlated with tau PET than with amyloid PET, with areas under the curve of 0.80 and 0.67, respectively.

Biogen reported pharmacokinetic and dose-finding data from studies of its anti-tau antibody BIIB076 in non-human primates. Taking a different tack, Asceneuron presented preclinical data on its O-GlcNAcase inhibitor ASN120290 (previously ASN-561), which prevents tau tangles from forming and earlier this month was approved to enter human trials.

2023年8月1日 · In search of chunks of tau in fluids that would signal the presence of tangles without the need for costly tau-PET scans, the WashU team previously identified MTBR-tau-243. Among a small number of participants in the Dominantly Inherited Alzheimer’s Network (DIAN), the researchers found that the mid-section fragment tracks with tau-PET and ...

2020年12月11日 · MTBR-tau species beginning at residue 243 correlate tightly with tau PET and cognitive measures, flag tangles in AD. Antibodies targeting tau’s mid-region may be more effective. Led by Kanta Horie and Randall Bateman at Washington University School of Medicine, St. Louis, the research team analyzed MTBR-tau species in AD and control CSF.

2021年2月13日 · The methodology is neat, using a photo-convertible tau Dendra2 virus to follow turnover of tau as well as inclusion of new protein in the same tangles over time. Their finding that tau tangles are dynamic structures could highlight the potential for increasing tau clearance from the brain and reducing tangle burden if the mechanisms behind ...

2022年5月5日 · The distribution of tau tracer uptake increases hierarchically according to Braak stage. [Courtesy of Therriault et al., Nature Aging, 2022.] By and large, tau pathology proceeded in a hierarchical fashion, meaning that tangles in later Braak stage regions only appeared in people who had tau tangles in earlier Braak stage regions, as well.

2024年8月2日 · Despite the correlation between tangles and slow-wave activity, Pase noted that other factors, such as ApoE4, could be involved, both driving tau pathology and disrupting NREM sleep (Tranah et al., 2018; Feb 2023 news; Nov 2019 news). To figure out causation, the scientists would need to follow the changes in slow waves over time, he said.

2024年9月20日 · In HEK293 cells, tau-RING cleared 80 percent of pre-existing tangles within 72 hours, and prevented new ones. Both approaches worked in mice as well. Benn and colleagues injected nanobody-RING into the frontal cortices of 6-month-old Tg2541 mice, which overexpress human P301S tau and have extensive tangles by then ( Allen et al., 2002 ).