Diversity of Macrophages in Lung Homeostasis and Diseases
Sep 23, 2021 · In this review, we will discuss the physiological characteristics and unique functions of these three types of macrophages in acute and chronic lung diseases. We will also discuss possible methods to target macrophages in lung diseases.
Biology of lung macrophages in health and disease - Cell Press
Sep 13, 2022 · First, we provide a guide to identifying and distinguishing lung macrophages from other mononuclear phagocytes in humans and mice. Second, we outline emerging concepts related to the development and function of the various lung macrophages in the alveolar, perivascular, and interstitial niches.
Editorial: Alveolar Macrophages in Lung Inflammation and …
Alveolar macrophages are the first line of defense against pollutants and pathogenic microbes that initiate an innate immune response in the lung. Two phenotypes of alveolar macrophages have been identified: classically activated macrophage (M1 macrophage) and alternatively activated macrophage (M2 macrophage).
Macrophages in Lung Injury, Repair, and Fibrosis - PubMed
Feb 18, 2021 · Macrophages are activated and polarized in response to lipopolysaccharide- or bleomycin-induced lung injury. The classically activated macrophage (M1) and alternatively activated macrophage (M2) have been extensively investigated in lung injury, repair, and fibrosis.
The Role of Macrophages in the Development of Acute and …
Alveolar macrophages (AMs) and interstitial macrophages (IMs) reside in the lungs. AMs are in close contact with the epithelial cells of alveoli, and IMs reside in the parenchyma between the microvascular endothelium and alveolar epithelium.
Pulmonary macrophages: key players in the innate defence of
Macrophages are the most numerous immune-cells present in the lung environment under homoeostatic conditions and are ideally positioned to dictate the innate defence of the airways. Pulmonary macrophage populations are heterogeneous and demonstrate remarkable plasticity, owing to variations in origin, tissue residency and environmental influences.
Biology of lung macrophages in health and disease - PubMed
Sep 13, 2022 · First, we provide a guide to identifying and distinguishing lung macrophages from other mononuclear phagocytes in humans and mice. Second, we outline emerging concepts related to the development and function of the various lung macrophages in the alveolar, perivascular, and interstitial niches.
The impact of the lung environment on macrophage …
Jan 11, 2022 · Despite their key roles in lung homeostasis, macrophages are implicated in the pathogenesis of many chronic lung pathologies, including pulmonary fibrosis (PF).
Pulmonary macrophages and their different roles in health and …
Dec 1, 2021 · The lung resident macrophages known as Alveolar Macrophages (AM) and Interstitial Macrophages (IM) are localized in two different compartments. During lung homeostasis, macrophages can remove inhaled particulates, cellular debris and contribute to some metabolic processes.
The role of monocyte-derived macrophages in the lung: It’s all …
Jun 1, 2023 · Macrophages are present in every tissue of the body where they play crucial roles in maintaining tissue homeostasis and providing front line defence against pathogens. Arguably, this is most important at mucosal barrier tissues, such as the lung and gut, which are major ports of entry for pathogens.
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