Lipid droplets, also referred to as lipid bodies, oil bodies or adiposomes, [1] are lipid-rich cellular organelles that regulate the storage and hydrolysis of neutral lipids and are found largely in the adipose tissue. [2]

2024年7月19日 · Lipid droplets (LDs) serve as cellular lipid storage depots. They are pivotal in various physiological processes, encompassing lipid metabolism, cell signaling, as well as energy storage [1]. The past few decades have seen significant progress in LD-related research.

2009年3月15日 · Lipid droplets (LDs) are the major cellular organelles for the storage of neutral lipids. Excessive lipid storage in LDs is central to the pathogenesis of prevalent metabolic diseases, such as obesity, diabetes and atherosclerosis; LDs are, therefore, crucial in the development of these diseases.

2018年12月6日 · Abstract | Lipid droplets are storage organelles at the centre of lipid and energy homeostasis. They have a unique architecture consisting of a hydrophobic core of neutral...

Lipid droplets play a critical role in an organism’s physiology; too many lipid droplets can result in obesity and too few in metabolic disease. In their first video, Drs. Farese and Walther introduce us to lipid droplets and explain their importance in cellular biology.

2017年6月29日 · Lipids are essential building blocks synthesized by complex molecular pathways and deposited as lipid droplets (LDs) in cells. LDs are evolutionary conserved organelles found in almost all organisms, from bacteria to mammals.

Here we review the current understanding of the mechanisms of lipid droplet biogenesis and turnover, the transfer of lipids and metabolites at membrane contact sites, and the role of lipid...

Delimited by a surfactant phospholipid monolayer, lipid droplets are evolutionarily conserved organelles that enable the secure storage of hydrophobic neutral lipids in the hydrophilic cytosol.

2008年6月11日 · Lipid droplets (LDs) are depots of neutral lipids that exist virtually in any kind of cell, ranging from bacteria to yeasts, plants, and higher mammals (Fig. 1a) (Murphy 2001). In the white adipocyte, an LD occupies the major portion of the cytoplasm and is …

2024年9月4日 · As an active organelle, lipid droplet (LD) varies dynamically with the metabolic state and energy requirements of cells. Early research established that LDs are crucial for lipid metabolism, with abnormalities often leading to lipotoxicity-related diseases, like diabetes, and fatty liver diseases [5].