- Here, we developed a trispecific antibody that interacts with CD38, CD3 and CD28 to enhance both T cell activation and tumor targeting.pubmed.ncbi.nlm.nih.gov/35121834/
Novel tri-specific tribodies induce strong T cell activation and anti ...
The promising results of the combined treatments prompted us to generate five novel tri-specific tribodies, as shown in Fig. 1A and B and listed in Table 1. The tribody is a multi-specific antibody construct made up of a Fab domain as a scaffold, in which Fd fragment of H-chain (VH + CH1) and L-chain (VL + CL) can naturally … 展开
To verify whether the novel human tribodies 53D, 53L1 and 53L10, derived from PD-1_1, PD-L1_1 and 10_12 antibody binding domains, respectively, retain the ability … 展开
Activation of T cell receptor (TCR)/CD3 on effector cells by novel tribodies and parental Tb535H was examined on 5T4-expressing CHO-K1 (CHO-5T4) cells, used … 展开
In vivo anti-tumor efficacy of the novel tribodies was evaluated on A-549 (human lung cancer cells) xenograft mouse models. Human PBMCs were activated by … 展开
Novel tri-specific T-cell engager targeting IL …
In this study, we report that a novel DNA-encoded tri-specific T cell engager (DTriTE) simultaneously targeting EGFRvIII and IL13Ra2 exhibits antigen-specific, potent tumor control in …
DR30318, a novel tri-specific T cell engager for Claudin 18.
2024年3月30日 · Based on the in-house screened anti-CLDN18.2 VHH, we have developed a novel tri-specific T cell engager targeting CLDN18.2 for gastric and pancreatic cancer …
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三特异性抗体在肿瘤免疫治疗中的研究进展
Abstract: Trispecific antibodies (TsAbs) are innovative therapies that target three different antigen-binding sites on tumor cells or immune effector cells simultaneously. Compared with …
IMT030122, A novel engineered EpCAM/CD3/4-1BB tri-specific …
2024年8月20日 · After considering the effectiveness, safety, half-life, and purification process of T cell-targeting antibodies, we developed a novel tri-specific antibody, IMT030122, using the X …
Trispecific T-cell engagers for dual tumor-targeting of colorectal ...
2022年2月7日 · Here, we describe a novel tandem T-cell recruiting trispecific antibody for the treatment of colorectal cancer (CRC). This construct, termed trispecific T-cell engager (TriTE), …
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Abstract LB128: A novel tri-specific T cell engager targeting BCMA …
2024年4月5日 · GBD218 is a novel tri-specific antibody that showed potent in vitro and in vivo anti-tumor activity. GBD218 efficiently kills both BCMA and/or GPRC5D expressing MM cells, …
Bi- and Tri-Specific T Cell Engager-Armed Oncolytic Viruses: Next ...
The design of a triple specific T cell engager (TriTE) antibody and how it links the T cells to the targeted cancer cells. This trispecific antibody binds three targets: the CD38 protein on a …
Bi- and trispecific immune cell engagers for immunotherapy of ...
2023年7月27日 · Trispecific antibodies (engaging either T cell or NK cell receptors) raise the game even further with a third binding moiety, which allows either the targeting of an additional …
Bi- and Tri-Specific T Cell Engager-Armed Oncolytic Viruses
2020年7月10日 · Bi- and tri-specific antibodies targeting tumor antigens and capable of activating T cell receptor signaling have also shown great promise in cancer immunotherapy. In a cutting …
