Apr 6, 2024 · Tertiary lymphoid structures (TLS) are clusters of immune cells that resemble and function similarly to secondary lymphoid organs (SLOs). While TLS is generally associated with an anti-tumour immune response in most cancer types, it has also been observed to act as a pro-tumour immune response.

Apr 15, 2024 · The formation of tertiary lymphoid structure (TLS) is a response to inflammatory stimulation mediated by different cytokines, and it can be divided into three steps: (i) interaction of lymphoid tissue inducer cells (LTi) and lymphoid tissue organizers (LTo); (ii) high endothelial venules (HEV) formation and immune cells recruitment; (iii) T/B ...

Aug 12, 2024 · Tertiary lymphoid structures (TLSs) are ectopic lymphoid aggregates formed by the structured accumulation of immune cells such as B cells and T cells in non-lymphoid tissues induced by infection, inflammation, and tumors.

Jan 15, 2021 · Under conditions of prolonged inflammation, tissue stromal cells acquire LN-like properties and drive the formation of hematopoietic aggregates, named tertiary lymphoid structures (TLSs). TLSs are continuously dependent on inflammatory stimuli, disappearing when inflammation is resolved (3 – 5).

Jan 15, 2025 · A research team at Memorial Sloan Kettering Cancer Center (MSK) has made new insights into how the body forms immune cell clusters called tertiary lymphoid structures (TLSs) in response to foreign threats such as cancer.

Jan 11, 2024 · We describe key factors (cytokines and chemokines) and cellular populations (stromal cells and high endothelial venules) involved in TLS development. Further, we explore attributes of a mature and functional TLS (follicular dendritic cell networks and germinal centers).

Dec 22, 2022 · TLSs, also termed tertiary lymphoid organs or ectopic lymphoid structures, are discrete and/or organized aggregates of infiltrating immune cells appearing in non-lymphoid tissues after birth.

Sep 23, 2021 · Tertiary lymphoid structures (TLS) are ectopic aggregates of lymphoid cells in inflamed, infected, or tumoral tissues that are easily recognized on an H&E histology slide as discrete entities, distinct from lymphocytes.

Dec 2, 2022 · A tertiary lymphoid structure (TLS) is a special component in the immune microenvironment that is mainly composed of tumor-infiltrating lymphocytes (TILs), including T cells, B cells, DC cells, and high endothelial venules (HEVs).

Tertiary lymphoid structures (TLS) are ectopic lymphoid formations that form within nonlymphoid tissue. They share structural and functional characteristics with secondary...