特非那定，是一种有机化合物，化学式为c32h41no2，是一种抗组胺药，有特异的外周h1受体拮抗作用，且没有抗5-羟色胺、抗胆碱能和抗肾上腺素能的作用。适用于季节性过敏性鼻炎（花粉症）、常年性过敏鼻炎、急慢性荨麻疹等的治疗。

Terfenadine is an antihistamine formerly used for the treatment of allergic conditions. It was brought to market by Hoechst Marion Roussel (now Sanofi) and was marketed under various brand names, including Seldane in the United States, Triludan in the United Kingdom, and Teldane in Australia. [1]

Terfenadine is an antihistamine. Antihistamines prevent sneezing, runny nose, itching and watering of the eyes, and other allergic symptoms. Terfenadine is used to treat allergies, hives (urticaria), and other allergic inflammatory conditions. Terfenadine may also be used for purposes other than those listed in this medication guide.

Terfenadine, an H1-receptor antagonist antihistamine, is similar in structure to astemizole and haloperidol, a butyrophenone antipsychotic. The active metabolite of terfenadine is fexofenadine. Mechanism of action. Terfenadine competes with histamine for binding at H1-receptor sites in the GI tract, uterus, large blood vessels, and bronchial ...

Terfenadine is a prodrug that is metabolized by intestinal CYP3A4 to the active form fexofenadine, a selective histamine H1-receptor antagonist with antihistaminic and non-sedative effects. Terfenadine's active metabolite competitively binds peripheral H1-receptors, thereby stabilizing an inactive conformation of the receptor.

Terfenadine is a prodrug that can cause serious cardiotoxicity. Terfenadine is transformed via the CYP3A4 system to its pharmacologically active acid metabolite, fexofenadine, which is a substituted benzene acetic acid (see Figure 28-1). Fexofenadine is not metabolized by the liver and is excreted essentially unchanged.

Terfenadine is a selective histamine H1-receptor antagonist which, in pharmacodynamic studies, is devoid of central nervous system depressant activity. In clinical studies terfenadine is well tolerated and at a dose of 60mg administered twice daily the drug provides effective relief of symptoms in p …

terfenadine, Seldane. What brand names are available for terfenadine? What brand names are available for terfenadine? Seldane. Related Disease Conditions. Chronic Rhinitis. Chronic rhinitis (non-allergic rhinitis) causes runny nose, sneezing, nasal itching, and congestion. Post-nasal drip is the drainage of mucus from the sinuses into the throat.

酮替芬可用于缓解和预防大多数季节性过敏相关的眼部瘙痒和刺激，起效时间约在给药后几分钟内，其药物代谢半衰期约为 12 小时。 该药物尚未在三岁以下儿童中进行过研究。 [1] [7] 除了抗组胺活性外，它还是一种功能性白三烯拮抗剂 [8] 和磷酸二酯酶抑制剂。[9]口服酮替酚在加拿大、欧洲 …

特非那丁(Terfenadine)是一種抗過敏藥物，具有止癢、緩解氣道平滑肌痙攣等作用。 在使用時需考慮心血管疾病史等風險因素，並注意可能發生的副作用和禁忌人群。