2014年10月5日 · Pimonidazole is a 2-nitroimidazole that is reductively activated specifically in hypoxic cells and forms stable adducts with thiol groups in proteins, peptides, and amino acids …

2014年12月2日 · Pimonidazole staining reflects an aggressive hypoxic phenotype of prostate cancer characterised by upregulation of proliferation, DNA repair and hypoxia response genes.

Hypoxic cells were recognized by immunohistochemical detection of pimonidazole using a mouse monoclonal antibody. Cell proliferation was detected with a commercially available monoclonal …

1998年11月1日 · The purpose of this study was to demonstrate the clinical feasibility of quantitative hypoxia detection with pimonidazole, a novel hypoxia marker, and to correlate …

Pimonidazole is a lipophilic 2-nitroimidazole with a basic side chain that, under physiological conditions exists as a racemic mixture of the R- and S-enantiomers. Pimonidazole is well …

2022年1月1日 · Pimonidazole can be easily administered and detected by immunohistochemistry, immunofluorescence, ELISA or flow cytometry. Here, we aim to evaluate the degree of …

The hypoxia marker pimonidazole is a candidate biomarker of cancer aggressiveness. We investigated the transcriptional programme associated with pimonidazole staining in prostate …

Pimonidazole is a 2-nitroimidazole with hypoxic selectivity and potential radiosensitizing activities. Pimonidazole is reduced in hypoxic environments such as those found in tumors. In hypoxic …

2016年8月31日 · Pimonidazole is a 2-nitroimidazole-based exogenous hypoxia marker extensively used for measuring tumor hypoxia by immunohistochemical staining in …

pimonidazole A nitroimidazole with hypoxic selectivity and radiosensitizing property. Pimonidazole is reduced in hypoxic environments as in tumor cells, thereby it can be used as an hypoxia …