Isoforms of receptors of fibroblast growth factors - PubMed
- DOI: 10.1002/jcp.24649
- 已发布: 2014/12
- Keywords: National Institutes of Health; National Center fo…
- Authors: Siew-Ging Gong
- 页数: 9
The breadth and scope of Fibroblast Growth Factor signaling is immense, with documentation of its role in almost every organism and system studied so far. FGF ligands signal through a family of four distinct tyrosine kinase receptors, the FGF receptors (FGFRs). One contribution to the diversity of f...Fibroblast growth factor receptor 1 - Wikipedia
FGFR1 is a member of the fibroblast growth factor receptor (FGFR) family, which in addition to FGFR1, includes FGFR2, FGFR3, FGFR4, and FGFRL1. FGFR1-4 are cell surface membrane receptors that possess tyrosine kinase activity. A full-length representative of these four receptors consists of an extracellular region composed of three immunoglobulin-like domains which bind their proper ligands, …
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Ligand specificity is determined by tissue-specific expression of isoforms, and differences in the third Ig-like domain are crucial for ligand specificity. Affinity for fibroblast growth factors (FGFs) …
- FGFR1 Isoforms 的研究
FGFR1 fibroblast growth factor receptor 1 [ (human)]
FGFR1-IIIb and FGFR1-IIIc are coexpressed, and the FGFR1-III isoforms are differentially regulated by growth factors and cyclin D1. bFGF, FGFR1, and FGFR2 are frequently …
Fibroblast Growth Factor Receptors (FGFRs): Structures …
The human fibroblast growth factor receptor (FGFR) family consists of four members: FGFR1 to FGFR4. Despite being encoded by separate genes, the four members share high homology, with their sequence identity varying from 56% …
The structure and function of vertebrate fibroblast growth factor ...
The vertebrate fibroblast growth factor receptor 1 (FGFR1) is alternatively spliced generating multiple splice variants that are differentially expressed during embryo development and in the …
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2024年12月18日 · An exon-skipping mechanism removes the D1 domain, giving rise to various isoforms of the receptor (FGFR1-FGFR3), while an alternative splicing process in the second …
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Recently, two small molecule inhibitors of FGFRs, ponatinib and AZD4547, have attracted huge attention. Ponatinib, a type II inhibitor, has high affinity towards FGFR1/4 isoforms, but …
Isoforms of Receptors of Fibroblast Growth Factors - Gong - 2014 ...
2014年4月15日 · A better understanding of the diversity of FGF signaling in different developmental contexts and diseased states can be achieved through increased knowledge of …
