Adiponectin is a hormone your adipose (fat) tissue releases that helps with insulin sensitivity and inflammation. Low levels of adiponectin are associated with several conditions, including obesity, Type 2 diabetes and atherosclerosis. What is adiponectin?

Adiponectin is a 244-amino-acid-long polypeptide (protein). It has four distinct regions: The first is a short signal sequence that targets the hormone for secretion outside the cell; next is a short region that varies between species; the third is a 65-amino acid region with similarity to collagenous proteins; the last is a globular domain.

Adiponectin is a circulating hormone secreted by adipose tissue which exerts protective effects against inflammation and can positively modulate the endocrine system, by enhancing insulin sensitivity in obese animals as well as in humans [1, 2].

2023年7月30日 · Adiponectin is the most abundant peptide hormone secreted by white adipocytes. Since discovering adiponectin in the 1990s, it has become a widely accepted biomarker for obesity-related diseases such as metabolic syndrome, Type 2 Diabetes mellitus, and atherosclerotic cardiovascular disease (ASCVD). [1] [2]

Adiponectin is the most abundant peptide secreted by adipocytes, whose reduction plays a central role in obesity-related diseases, including insulin resistance/type 2 diabetes and cardiovascular disease. In addition to adipocytes, other cell types, such as skeletal and cardiac myocytes and endothelial cells, can also produce this adipocytokine.

2020年9月3日 · Adiponectin, an adipokine secreted by adipocytes, is a well-known homeostatic factor for regulating glucose levels, lipid metabolism, and insulin sensitivity through its anti-inflammatory, anti-fibrotic, and antioxidant effects.

Adiponectin, an adipokine secreted by adipocytes, is a well-known homeostatic factor for regulating glucose levels, lipid metabolism, and insulin sensitivity through its anti-inflammatory, anti-fibrotic, and antioxidant effects. All these metabolic processes are mediated via two adiponectin receptors, AdipoR1 and AdipoR2.

In summary, adiponectin is an essential protein involved in the regulation of glucose and lipid metabolism. Its role in improving insulin sensitivity and reducing inflammation makes it a key player in combating obesity and metabolic disorders.

2019年3月14日 · Adiponectin, first described in the mid-1990s, is one of the most widely studied adipokines to date. Studies of its regulation, biogenesis and physiological effects have yielded great insight and...

2018年6月18日 · Adiponectin's anti-inflammatory and anti-apoptotic properties results in protection of the vasculature, heart, lung, and colon. In this review, we provide a comprehensive overview of the discovery, protein structure, receptors, expression, regulation, and physiological functions of adiponectin. © 2017 American Physiological Society.