The Myc family consists of three related human genes: c-myc , l-myc , and n-myc . c-myc (also sometimes referred to as MYC) was the first gene to be discovered in this family, due to …

Induced c-Myc overexpression coordinates the expression of genes necessary for cells to engage in glutamine catabolism that exceeds the cellular requirement for protein and nucleotide …

The c-myc gene was discovered as the cellular homolog of the retroviral v-myc oncogene 20 years ago (23, 25, 167). The c-myc proto-oncogene was subsequently found to be activated in …

This paper demonstrates the multiple innate oncogenic properties of c-Myc activation in vivo, when c-Myc-induced apoptosis is inhibited.

The MYC oncogene (also known as c-MYC) is part of a superfamily of genes with products that are among the most commonly activated in human cancers 1–4. MYC is a master regulator of …

2021年1月4日 · c-Myc is a transcription factor that is constitutively and aberrantly expressed in over 70% of human cancers. Its direct inhibition has been shown to trigger rapid tumor …

2012年10月15日 · The effects induced by c-Myc can occur either as a "primary oncogene" which is activated by amplification or translocation or as a downstream effect of other activated …

This review summarizes progress in controlling the extent of c-Myc transcription, translation, interaction with other myc network members, DNA binding and transcriptional activation.

2024年12月25日 · MYC (MYC Proto-Oncogene, BHLH Transcription Factor) is a Protein Coding gene. Diseases associated with MYC include Burkitt Lymphoma and High-Grade B-Cell …

C-MYC expression promoted high proliferation rates of MSC, attenuated but not abrogated their differentiation capacity, and did not immediately lead to tumor formation in the tested in vivo …