2024年6月28日 · The mediastinum is commonly involved in systemic lymphomas. Approximately 60% of all Hodgkin lymphoma and 20% of non-Hodgkin lymphoma involves the mediastinum at presentation. Less frequently, the disease is isolated to the mediastinum (3% Hodgkin lymphoma, <10% non-Hodgkin lymphoma) 1.

2022年12月13日 · Mediastinal tumors are rare, occurring in less than 1% of the population. Most form in the anterior (front) part of your mediastinum. The most common types are thymomas, benign mediastinal cysts and lymphomas.

Primary mediastinal large B cell lymphoma (PMBL) is an aggressive B cell lymphoma that is thought to arise from thymic (medullary) B cells. It has clinicopathologic features that are distinct from systemic diffuse large B cell lymphoma (DLBCL) and shares some clinical and biologic features with nodular sclerosing classic Hodgkin lymphoma (cHL).

Hodgkin's lymphoma (HL), primary mediastinal B-cell lymphoma (PMBCL) and T-lymphoblastic lymphoma (TLL) are the most common primary mediastinal lymphomas. This study aims to detail the histological features of mediastinal lymphomas diagnosed in our Institute, to discuss the close differentials and to compare the morphological and ...

Primary mediastinal B-cell lymphoma (PMBCL) is relatively rare B-cell non-Hodgkin lymphoma that comprises 6–12% of all diffuse large B-cell lymphomas (DLBCLs) and 2–4% of all non-Hodgkin...

2022年9月1日 · Primary mediastinal large B-cell lymphoma (PMBCL) is a separate entity in the World Health Organization’s classification, based on clinicopathologic features and a distinct molecular signature that overlaps with nodular sclerosis classic Hodgkin lymphoma (cHL).

Primary mediastinal large B cell lymphoma (PMBCL) is an aggressive large B cell lymphoma originating in the mediastinum, that mainly expresses B cell surface molecules, such as CD19, CD20, CD22, andCD79a. Clinically, they are characterized by ...

2020年9月5日 · Primary mediastinal B-cell lymphoma originates in the mediastinum and is managed like the early stage of diffuse large B-cell lymphoma (DLBCL). The primary treatment is around 6 courses of cyclophosphamide, doxorubicin, vincristine, prednisone (CHOP), and rituximab (R-CHOP). This could be followed by radiation to the mediastinum in suitable ...

Lymphoma is the most common malignancy involving the mediastinum but can be challenging to diagnose on small biopsy specimens. This review provides a pattern-based approach to help triage small tissue samples for the diagnosis of mediastinal lymphoid proliferations, with focus on the main primary me …

2023年6月8日 · Primary mediastinal B cell lymphoma (PMBCL) is a rare and aggressive disease that tends to occur in young females as a large mediastinal mass with local invasion. 1 Tumor cells originate from thymic B cells with overlapping features between diffuse large B cell lymphoma (DLBCL) and classical Hodgkin lymphoma (cHL). 2 The 4th and 5th WHO ...