Apoptosis regulator BAX, also known as bcl-2-like protein 4, is a protein that in humans is encoded by the BAX gene. [5] BAX is a member of the Bcl-2 gene family. BCL2 family …

2023年1月30日 · The BAX gene (Bcl-2 Associated X-protein) is a pro-apoptotic member of the Bcl-2 gene family; it encodes a 21-kDa protein named BAX-alpha, whose association with Bcl …

2024年12月24日 · BAX (BCL2 Associated X, Apoptosis Regulator) is a Protein Coding gene. Diseases associated with BAX include Colorectal Cancer and T-Cell Acute Lymphoblastic …

2025年1月4日 · In the exone 3 of the gene Bax mutation G7/G9 in cells SKOV3 results in an inactivation of proapoptotic activity of the protein Bax. BAX is required for TRAIL/Apo2L …

2023年1月30日 · The BAX gene (Bcl-2 Associated X-protein) is a pro-apoptotic member of the Bcl-2 gene family; it encodes a 21-kDa protein named BAX-alpha, whose association with Bcl …

BAX is the first BCL-2-associated protein identified by immunoprecipitation and yeast two-hybrid screening . BAX proteins mainly have domains with familial structural characteristics: BH1, …

Under normal conditions, BAX is largely cytosolic via constant retrotranslocation from mitochondria to the cytosol mediated by BCL2L1/Bcl-xL, which avoids accumulation of toxic …

2006年6月2日 · In mammals, the multidomain proteins (MDPs) of the Bcl-2 family include Bax, Bak, and Bok. The founding member of the MDP group of Bcl-2-family proteins was …

2025年1月4日 · The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript …

Bax, a central cell death regulator, is an indispensable gateway to mitochondrial dysfunction and a major pro-apoptotic member of the Bcl-2 family proteins that control apoptosis in normal and …