Since the identification of B cells in 1965 (Cooper et al. 1965), three has been tremendous progress in our understanding of B cell development, maturation and function. A number of B cell subpopulations, including B-1, B-2 and regulatory B cells, have been identified.

2022年8月11日 · We shall now discuss the seven B cell development stages here. Beginning with the most primitive stage we shall walk through to the most advanced that gives rise to the mature B cells. The mature functional B cells protect you as part of the adaptive immune system. 1. Stem cell. This is the first stage of B cell development.

2008年9月1日 · Early B-cell development is characterized by the ordered rearrangement of Ig H and L chain loci, and Ig proteins themselves play an active role in regulating B-cell development. 31 Pivotal to understanding how early B-cell development is regulated was the discovery of surrogate L chains (SLCs).

B cells undergo two types of selection while developing in the bone marrow to ensure proper development, both involving B cell receptors (BCR) on the surface of the cell. Positive selection occurs through antigen-independent signalling involving both the pre-BCR and the BCR.

The maturation of B cells is a tightly regulated process that ensures the development of a diverse B cell repertoire capable of recognizing a wide range of antigens while avoiding harmful self-reactivity.

2014年11月13日 · Overview of B cell development • B cells are generated in the bone marrow • Takes 1-2 weeks to develop from hematopoietic stem cells to mature B cells • Sequence of expression of cell surface receptor and adhesion molecules which allows for differentiation of B cells, proliferation at various stages, and movement

B-cell development. The figure shows the broad outline of B-cell developmental stages in mice and humans. B-1a, B-1b, and B10 populations are less well characterized in humans. CLP indicates common lymphoid progenitor; SHM, somatic hypermutation; and CSR, class switch recombination. Illustration by A. Y. Chen.

2021年4月9日 · The prerequisite for the development of B cells is the absence or suppression of protein Notch-1 signaling in the bone marrow. The overall development of B cells occurs following the stages of maturation, activation, differentiation, and memory generation.

2023年9月26日 · The B lymphocyte (B cell) is one of the most important cells of the body. These cells form part of the adaptive immune response by producing antibodies and presenting antigens to T cells. Once activated, they can mature into plasma cells or memory B lymphocytes. This article covers B cell development and subtypes.

Here we provide an overview of the current understanding of B cell development and function and briefly describe inborn errors of immunity associated with B cell development defects which can manifest as immune deficiency, malignancy, autoimmunity, or allergy.