Amidination of ligands for chemical and field-effect ... - Science
2024年11月21日 · Bimolecular passivation, in which two molecules provide field-effect and chemical passivation, respectively, such as the PDAI 2 /3MTPAI combination, can repel hole carriers and interact with defect sites to form chemical bonds, thereby reducing complex carrier recombination at the perovskite–electron transport layer (ETL) interface . Instead ...
Chemical remodeling of a cellular chaperone to target the
2023年8月17日 · Their complex formation was the product of purposeful, structure-guided chemical modifications to mold a high-affinity binding interface between CYPA and active KRAS G12C. The target-directed approach described here differs from other pharmacologic or proteomic screens that describe the identification of rapamycin or sangliferin analogs that ...
Large-scale chemoproteomics expedites ligand discovery and
Chemical modulation of proteins enables a mechanistic understanding of biology and represents the foundation of most therapeutics. However, despite decades of research, 80% of the human proteome lacks functional ligands. Chemical proteomics has advanced ...
Chemical Science and Technology
Department of Chemistry, Duke University, Durham, North Carolina 27706, and Advisory Committee for Chemistry, National Science Foundation, Washington, D.C. 20550
We need a global science-policy body on chemicals and waste
2021年2月19日 · The wealth of knowledge and experience of IPCC, IPBES, and other interface bodies (see SM) offers important insights for designing an overarching science-policy interface body on chemicals and waste (although each thematic area and science-policy interface body has its own distinctive characteristics that need to be taken into consideration).
Roaming in highly excited states: The central atom ... - Science
2024年2月15日 · Funding: The experimental work was supported by the National Natural Science Foundation of China (grants 22241304 and 22225303); the National Natural Science Foundation of China (NSFC Center for Chemical Dynamics) (grant 22288201); the Scientific Instrument Developing Project of the Chinese Academy of Sciences (grant GJJSTD20220001), the ...
Neurotoxic mixture effects of chemicals extracted from blood
2024年10月17日 · Human biomonitoring studies typically capture only a small and unknown fraction of the entire chemical universe. We combined chemical analysis with a high-throughput in vitro assay for neurotoxicity to capture complex mixtures of organic chemicals in ...
A synthetic polymer system with repeatable chemical recyclability
2018年4月27日 · In contrast, chemical recycling (12, 13) can allow for recovery of the precursor building block chemicals via depolymerization or creative reuse or repurposing through the generation of value-added materials (14–16). With specifically designed monomers, reaction conditions can be used to select the direction of the monomer-polymer equilibrium ...
Chemical simplification and tracking in plastics | Science - AAAS
2023年11月2日 · Chemical additives known to cause harm to human health and the environment must be rapidly phased out, and NIASes must be identified and limited. To ensure these changes, plastics producers should transparently report chemicals production and use, which should be tracked and monitored throughout the plastics life cycle.
Recording physiological history of cells with chemical labeling
2024年2月22日 · The fluorescent marks resisted chemical fixation (Fig. 4A and fig. S14), and labeling times as short as 5 min were sufficient to detect a difference between treated and untreated cells (fig. S15). Moreover, a variety of fluorescent substrates allowed thapsigargin-dependent fluorescent marking of cells ( Fig. 4C ).