Amidination of ligands for chemical and field-effect ... - Science
2024年11月21日 · Bimolecular passivation, in which two molecules provide field-effect and chemical passivation, respectively, such as the PDAI 2 /3MTPAI combination, can repel hole carriers and interact with defect sites to form chemical bonds, thereby reducing complex carrier recombination at the perovskite–electron transport layer (ETL) interface . Instead ...
Chemical remodeling of a cellular chaperone to target the
Their complex formation was the product of purposeful, structure-guided chemical modifications to mold a high-affinity binding interface between CYPA and active KRAS G12C. The target-directed approach described here differs from other pharmacologic or proteomic screens that describe the identification of rapamycin or sangliferin analogs that ...
Large-scale chemoproteomics expedites ligand discovery and
Chemical modulation of proteins enables a mechanistic understanding of biology and represents the foundation of most therapeutics. However, despite decades of research, 80% of the human proteome lacks functional ligands. Chemical proteomics has advanced ...
Recording physiological history of cells with chemical labeling
2024年2月22日 · The fluorescent marks resisted chemical fixation (Fig. 4A and fig. S14), and labeling times as short as 5 min were sufficient to detect a difference between treated and untreated cells (fig. S15). Moreover, a variety of fluorescent substrates allowed thapsigargin-dependent fluorescent marking of cells ( Fig. 4C ).
Chemical scissor–mediated structural editing of layered ... - Science
2023年3月16日 · The chemical scissor–mediated structural editing protocol contains four reaction routes : (i) the opening of non-vdW gaps in MAX phases by LAMS scissors because of differences in redox potential between Lewis acidic cations and A elements (route I), (ii) the diffusion of metal atoms into interlayer atom vacancies to form MAX phases to lower ...
We need a global science-policy body on chemicals and waste
2021年2月19日 · The wealth of knowledge and experience of IPCC, IPBES, and other interface bodies (see SM) offers important insights for designing an overarching science-policy interface body on chemicals and waste (although each thematic area and science-policy interface body has its own distinctive characteristics that need to be taken into consideration).
Chemical genetic approaches to dissect microbiota mechanisms
Determining the chemical and biological mechanisms of these processes has been a challenge addressed through genetics, biochemistry, and chemical biology tools. Yang et al . have reviewed recent advances in understanding how the microbiota function, in particular outlining tools and conceptual approaches.
Synthesis of Proteins by Native Chemical Ligation | Science - AAAS
1994年11月4日 · liu, c.f., chemical ligation approach to form a peptide-bond between unprotected peptide segments - concept and model study, journal of the american chemical society 116: 4149 (1994). Google Scholar MILLER, M, STRUCTURE OF COMPLEX OF SYNTHETIC HIV-1 PROTEASE WITH A SUBSTRATE-BASED INHIBITOR AT 2.3-A RESOLUTION, SCIENCE …
Human health effects of chemical mixtures | Science - AAAS
2022年2月17日 · Standard chemical risk assessment consists of several steps, including quantification of chemical exposure for a given population (exposure assessment), determination of safe concentrations for chemicals (hazard identification and characterization), and estimation of the health risks associated with exposures (risk characterization) . Over the ...
3D nanoprinting of semiconductor quantum dots by ... - Science
2022年9月1日 · In the present work, taking semiconductor quantum dots (QDs) as an example, we propose a strategy that uses electron-hole pairs generated by photoexcitation to modify the surface chemistry of QDs to induce interparticle chemical bonding, which we call photoexcitation-induced chemical bonding (PEB). Figure 1A illustrates the design concept ...