Plasma cells (PCs) are the terminal differentiation stage of activated B cells and serve as crucial effector cells in humoral immunity. While PCs have ...

The aim of this project is to understand the structure and function of epigenome loops for cell differentiation.We will focus on the differentiation of plasma cells, which produce antibody, as a model ...

Here the authors reveal that in addition to promoting class switch recombination via inhibition of DNA end processing, RIF1 fine-tunes the kinetics of plasma cell differentiation, thus providing ...

In striking contrast to the conventional plasma membrane FcRs ... One of the major research projects in the Hu laboratory is to study Tfh cell differentiation and germinal center (GC) responses. The ...