Hypospadias is a widespread congenital disorder, characterized by an abnormal placement of the urethral opening, impacting as ...

A recent study has uncovered the pivotal role of the transcription factor SOX9 in the development of hypospadias, a common ...

The journal Advanced Materials recently published a study introducing a new method for monitoring molecular processes deep ...

在这项研究中，研究人员根据ECM降解能力对巨噬细胞异质性进行了分类。一方面，提出了细胞外周的应力纤维参与细胞内溶酶体降解的ECM蛋白运输的证据。另一方面，VIM的破坏导致分散的内部足体组织并损害ECM降解，这是CD11b介导的过程。进一步描述了培养的极化巨噬细胞和患者TAMs中肌动蛋白和VIM组织的差异，并将其与ECM降解能力相关联。总之，该研究通过深入探究巨噬细胞内部的细胞骨架结构，揭示了中间丝 ...

Natural human monoclonal antibodies obtained from sentinel lymph nodes of cancer patients identify cell surface vimentin. One of these vimentin-reactive antibodies, pritumumab, has been used to treat ...

03 3.缺氧诱导人非小细胞肺癌细胞EMT和干性缺氧细胞呈间质化改变，HIF-1a、Snail、N-cadherin和Vimentin表达上调，而E-cadherin表达下调。缺氧细胞球体形成 ...

Department of Chemistry, University of Wisconsin-Madison, 1101 University Ave., Madison, Wisconsin 53706, United States Department of Cell and Regenerative Biology, University of Wisconsin-Madison, ...

Vimentin is a type III intermediate filament (IF) protein normally expressed in cells that develop into connective tissue, blood vessels, and lymphatic tissue (mesenchymal cells). Despite being widely ...

Additionally, CRISPR/Cas gene editing was applied to healthy stem cells to study the roles of GFAP and vimentin. The absence of both proteins impaired organoid development, particularly in the cortex.

Changes to the intermediate filament (IF) protein, vimentin, were found to promote tumor growth by increasing cancer stemness in an estrogen independent manner. Targeting vimentin and/or the long ...

Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou, Jiangsu 221004, China Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou ...