The results highlight an important physiological function of PGAM in the differentiation and suppressive activity of Treg cells by regulating serine synthesis. This role is proposed to intersect with ...

TYK2 inhibitors could represent a new class of drugs that inhibit interferon signatures and interleukin (IL)-12 signalling while preserving IL-2-mediated Treg cell differentiation, unlike other Janus ...

on DCs’ immune tolerance and regulatory T (Treg) cell differentiation. G protein-coupled receptors (GPCR) inhibitor and TGF-b-neutralizing antibody were used to explore the intrinsic mechanisms of ...

The differentiation of CD4 T cells into T helper 1 (TH1) or T follicular helper (TFH) subsets is often critical for controlling tumors, while their transformation into regulatory T cells (Tregs ...

Despite an increasing repertoire of therapeutic targets, a significant proportion of patients suffer chronic morbidity. Studies in mice and humans have highlighted the critical role of regulatory T ...

Harvard Medical School research reveals highly specialized regulatory T cells that curb inflammation and act as gatekeepers to protect the inner regions of the brain. The work, which was done in mice, ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. This study identifies combinations of TFs that ...