Genetically modified mice hint at tau hyperphosphorylation's early role in neurodegenerative diseases
Tau is a microtubule-associated protein that helps to stabilize the structure of neurons, specifically by supporting ...
Nature3mon
Tau protein abnormalities correlate with the severity of dementia in Alzheimer's disease
They consist of aggregates of abnormally phosphorylated tau proteins that are altered in conformation. Conformational changes in tau proteins are thought to be the earliest neurobiological changes ...
Hosted on MSN27d
Study explores association between Tau filaments and extracellular vesicles in Alzheimer's disease
Tau protein is a microtubule-associated protein (MAP) known to stabilize the internal structure of neurons, binding to microtubules. These are microscopic tubular structures that support the ...
eLife3d
Twelve phosphomimetic mutations induce the assembly of recombinant full-length human tau into paired helical filaments
This manuscript describes the identification and characterization of 12 specific phosphomimetic mutations in the recombinant full-length human tau protein that trigger tau to form fibrils. This ...
eLife5d
A New Role for RNA G-quadruplexes in Aging and Alzheimer’s Disease
The current human tissue-based study provides convincing evidence correlating hippocampal expressions of RNA guanine-rich G-quadruplexes with aging and with Alzheimer's Disease presence and severity.