Tau is a microtubule-associated protein that helps to stabilize the structure of neurons, specifically by supporting ...

This manuscript describes the identification and characterization of 12 specific phosphomimetic mutations in the recombinant full-length human tau protein that trigger tau to form fibrils. This ...

Tau protein is a microtubule-associated protein (MAP) known to stabilize the internal structure of neurons, binding to microtubules. These are microscopic tubular structures that support the ...

The current human tissue-based study provides convincing evidence correlating hippocampal expressions of RNA guanine-rich G-quadruplexes with aging and with Alzheimer's Disease presence and severity.

People with Alzheimer’s disease (AD) have a build-up of tau proteins in the brain which stick together and become tangled. These ‘tangles’ damage the internal structure of nerve cells affecting how ...

The study has been published in Cell Reports. It revealed how tau protein, often viewed as harmful in Alzheimer's, might initially protect the brain from the virus but contribute to brain damage ...

A key pathological hallmark of Alzheimer’s are filamentous inclusions made of the microtubule associated protein Tau. Based on alternative splicing, Tau protein can feature either three or four ...

New study led by Prof Karen Duff, Dr Naoto Watamura, & Dr Martha Foiani (UK DRI at UCL) with Prof Takaomi Saido (Riken Center for Brain Science, Japan) reveals insight into the early stages of toxic ...