Other brain-specific proteins such as neuron specific enolase (NSE), S-100b, and tau protein have also been reported to be increased in the CSF of patients with sporadic CJD. In 1996 a variant of CJD ...

Jan. 15, 2025 — Most treatments being pursued today to protect against Alzheimer's disease focus on amyloid plaques and tau tangles that accumulate in the brain, but new research points to a ...

The case we make here is simple. For animal models of concussion, TBI, and CTE to be clinically informative and translationally useful, these models must be grounded by: (i) clarity of definitions ...

We often hear the word “concussion” associated with athletic injuries, but anyone can be susceptible to this mild traumatic brain injury. Concussions result in an alteration of brain function, caused ...

For example, diffuse axonal injury is implicated in disrupting microtubule function, providing the potential context for pathologies of tau and amyloid to develop. The neuropathology of post-traumatic ...

Tau is a protein that is found in cells of the central nervous system and is involved in the assembly and stabilisation of neuronal microtubules – channels used to transport substances to ...

Tau is a protein that is found in cells of the central nervous system and is involved in the assembly and stabilisation of neuronal microtubules – channels used to transport substances to ...

The project focuses on uncovering the complex relationship between two key proteins, TDP-43 and Tau, and how their dynamic interactions contribute to disease. Dr. Michelle Steinhilb from Central ...

After hours: February 4 at 6:07:35 PM EST Loading Chart for DRTS ...

We co-stained BG4 with different p-tau epitope antibodies to determine whether pathological aggregation of tau proteins co-occurred with BG4 immunostaining (Fig. 4). Indeed, we found that BG4 ...

In this study, we demonstrate that the SHARD method significantly enhances the immunostaining of glial fibrillary acidic protein (GFAP), an astrocytic cytoskeletal marker ... Through these stains, ...