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Nature Aging | 免疫系统衰退的幕后推手:Sema4A缺失如何加速衰老进程?
在骨髓中,myHSCs和淋巴系造血干细胞(lyHSCs)的数量对比进一步显示了Sema4A缺失对髓系细胞的过度偏向(g、h)。特别是髓系前体细胞(MyPro)和红系前体细胞(CFU-E)的数量变化,也支持了Sema4A缺失与髓系扩展的关系。
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