This paper presents the important finding that BNIP3/NIX, a mitophagy receptor, and its binding to ATG18 are required for mitophagy during muscle cell reorganization in Drosophila. Although the ...

Cassava's strong liquidity with $128.6 million in cash supports early-stage development, yet long-term funding needs may lead ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Internal translation initiation sites, as ...

mTOR, Rictor, and DEPTOR (highlighted in red color in the figure). Upstream signals regulate mTORC1 activity mainly through two mechanisms: by direct control of mTORC1 components or by the supervision ...

and other physiological activities through PI3K/Akt/mTOR pathway. Normally, TSC1/TSC2 forms a dimer complex, which is an inhibitor of small GTPase Rheb, and Rheb is a necessary stimulating protein for ...

The membrane-associated E3 ubiquitin ligase ZNRF2 is released into the cytosol upon its phosphorylation by Akt. In this study, we show that ZNRF2 interacts with mTOR on membranes, promoting the amino ...