This article explores how broadly neutralizing antibodies are being researched, not only for their potential in the ...

Antibody therapies are a type of biologic. They are typically monoclonal antibodies selected to bind to a particular protein (often a cell-surface protein), and produced using recombinant DNA ...

In this manuscript, the authors describe a new AlphaFold2 pipeline called PabFold that can represent a useful tool for identifying linear antibody epitopes (B-cell epitopes) for different antigens.

Alignment of AlphaFold2 predicted scFv structures to an anti-c-Myc Fab crystal structure. A) Alignments of AlphaFold2-derived wild-type Myc scFv, Myc-2E2 scFv, and Myc-15F11 scFv structures with a Myc ...

However, as the conformational unmasking requires some physical forces between epitope and paratope, this model cannot easily explain the BCR triggering by the soluble format of monovalent antigens ...

1 Department of Pharmaceutics, Rutgers University, Piscataway, NJ, United States 2 Cancer Pharmacology Program, Cancer Institute of New Jersey, New Brunswick, NJ, United States This review article ...

Unit of Biophysics, Department of Biochemistry and Molecular Biology, Facultat de Medicina, Av. Can Domènech s/n, Universitat Autònoma de Barcelona, 08193 Cerdanyola del Vallès, Catalonia, Spain ...