Loss of SMAD4 induces PGK1 upregulation in PDAC, which enhances glycolysis and aggressive tumour behaviour. Notably, in SMAD4-negative PDAC, nuclear PGK1 preferentially drives cell metastasis via ...

The lncRNA NEAT1 can stabilize the structure of PGK1 by binding to PGK1, which mediates the glycolysis/lactate/HIF-1α pathway by increasing LDH activity, but HIF-1 can promote lactate efflux by ...

Parkinson’s disease (PD) involves the disruption of brain energy homeostasis. This encompasses broad-impact factors such as mitochondrial dysfunction, impaired glycolysis, and other metabolic ...

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