A preliminary experiment was conducted to determine the response of microglia to varying doses of LPS. Microglia were exposed to 1 ng/ml, 10 ng/ml and 100 ng/ml of TNFα for 24 hours. This ...

Oligodendrocyte progenitor cells (OPCs) are the major source of newly formed myelinating cells in the CNS. Thus, we studied in vitro platelets - OPCs interactions. Consistent with these observations, ...

One-Person Company registration is a popular choice for entrepreneurs seeking limited liability and a separate legal entity. An OPC is a unique business structure that allows a single individual to ...

The expression of GPR17 is uniquely restricted to oligodendrocyte lineage cells and decreases significantly as these cells mature into myelinating oligodendrocytes. Dysregulation of GPR17 has been ...

Not revised: This Reviewed Preprint includes the authors’ original preprint (without revision), an eLife assessment, and public reviews. This study presents convincing findings that oligodendrocytes ...

reduce apoptosis and increase survival of mature oligodendrocytes in vitro. The effects of activated microglia on OPC and oligodendrocyte viability are present even as microglia themselves undergo ...

1 Department of Cellular Neurophysiology, Institute of Experimental Medicine, Academy of Sciences of the Czech Republic (ASCR), Prague, Czechia 2 Second Faculty of Medicine, Charles University, Prague ...

2019). They demonstrated that, as opposed to the control group, animals treated with hP-MSCs and hP-MSC-EVs displayed increased “differentiation of endogenous oligodendrocyte precursor cells into ...

Mature oligodendrocytes (stained for galactocerebroside) are stained green. Figure 3 Adult human progenitors grown in cell culture and stained with the monoclonal antibody O4 can exhibit a ...