Pyramidal neuron. Neurofibrillary tangles. Light micrograph of a human cerebral cortex showing neurofibrillary tangles in several pyramidal neurons. Neurofibrillary tangles (NFTs) are a characteristic ...
LY3372689 was designed to slow the accumulation of hyper-phosphorylated, insoluble tau aggregates in the central nervous system, which clump together to form neurofibrillary 'tangles', one of the ...
In conditions like Alzheimer's and frontotemporal dementia, tau proteins become damaged, detach, and form toxic neurofibrillary tangles that harm neurons. This damage disrupts communication in the ...