Following the discovery of inhibitory KIR and the understanding that they play a role in preventing NK cell killing of self MHC I-expressing tumor cells, investigators began to research the ...

Hybrid resistance was mapped to several putative Hh loci located close to MHC class I genes, but no corresponding genes or antigens were ever found. I struggled with the issue of NK cell ...

whereas primate NK cells use immunoglobulin-based killer cell immunoglobulin-like receptors (KIRs) to recognize MHC class I-associated ligands, which control their activation 5. As if ...

Creating cancer therapies based around natural killer cells could offer similar levels of efficacy to CAR-T therapies, but at around one hundredth of the cost. Researchers at MD Anderson Cancer ...

For the new therapy, these cells are derived from stem cells that originated from healthy adult donor tissue - called induced pluripotent stem cells (iPSCs) - to make therapeutic CAR-NK cells.

CLN-619, an intravenously administered anti-MICA humanized IgG1 monoclonal antibody, is designed to inhibit MHC class I polypeptide ... and lysis of NK-mediated tumour cells.

[136] Understanding the role of MHC class I recognition by NK cells is rapidly evolving and stems from early observations that target sensitivity to NK lysis is inversely related to expression of ...