Following the discovery of inhibitory KIR and the understanding that they play a role in preventing NK cell killing of self MHC I-expressing tumor cells, investigators began to research the ...

[136] Understanding the role of MHC class I recognition by NK cells is rapidly evolving and stems from early observations that target sensitivity to NK lysis is inversely related to expression of ...

Recently developed major histocompatibility complex (MHC) multimer technologies allow visualization and isolation of antigen-specific T cells. However, functional analysis and in vivo transfer of ...

Natural killer (NK) cells have garnered attention for CAR-based therapy due to their inherent anti-cancer properties, minimal induction of cytokine release syndrome (CRS), and lack of MHC restrictions ...

This valuable study provides solid in vivo data that transfer of IL-15/IL-12-conditioned syngeneic NK cells after primary tumor resection promotes long-term survival of mice with low metastatic burden ...

They provide convincing evidence for the effectiveness of IL-15/12-conditioned NK cells in this design, which was also critical for the authors being able to conclusively reveal the T cell-dependency ...

For the new therapy, these cells are derived from stem cells that originated from healthy adult donor tissue - called induced pluripotent stem cells (iPSCs) - to make therapeutic CAR-NK cells.

Applying chimeric antigen receptor (CAR) technology to natural killer (NK) cells may offer safe, effective, and affordable therapies that enhance cancer immune surveillance. Methods: Here, we assess ...

Gilead Sciences' cell therapy Kite Pharma has bulked up its position in natural killer (NK) cell therapies, pledging up to $2.3 billion for a partnership with Shoreline Bioscience focusing on off ...

Department of Pathology, UMass Chan Medical School, Worcester, Massachusetts.

Induces potent and long-lasting immune responses to defined antigens or whole pathogens (particles), mainly through the ...