The mechanisms that cause these symptoms are not fully understood. The stress of heat and oxidative damage during exercise causes disruption to intestinal epithelial cell tight junction proteins ...
Disruption of these tight junctions increases the permeability of this barrier and, according to the study authors, may result in periglomerular inflammation. As lead researcher Stuart Shankland ...
The brain can influence commensal organisms (enteric microbiota) indirectly, via changes in gastrointestinal motility and secretion, and intestinal permeability, or directly, via signaling ...