Intestinal stem cells are multipotent adult stem cells, which in mammals reside in the base of the crypts of the adult intestine. Intestinal stem cells continuously self-renew by dividing and ...

Others suggest there's a dormant population of stem ... cell RNA sequencing to characterize all the cells in the crypts, the region of the intestine where the stem cells are known to reside ...

an increased depth of intestinal crypts, an elevation of the mitotic and the labeling index of crypt cells, and a decrease in the ratio of height of the villi to depth of the crypts. Metabolically ...

An IBEC-led study describes the development of an innovative method to control the formation of crypt-like structures and villi in the intestine using a contact protein printing technique. This model ...

In a recently published Science paper, 1 his team described how they developed a biomaterial tissue scaffold that allows intestinal stem cells to self-organize into organoids with patterned crypt-like ...

the epithelium undergoes rapid cellular turnover and regenerates continuously from multipotent intestinal stem cells (ISCs) present at the crypt base. During homeostasis, the ISC niche exists in the ...

We spatiotemporally pattern these cues using photoinduced degradation, viscoelasticity, and bond formation to study how intestinal stem cell colonies respond to alterations in geometric confinement, ...

The method developed by IBEC's Biomimetic Systems for Cell ... of intestinal epithelial tissue. Using this technique, the researchers were able to control how and where structures such as crypts ...

displaying typical ‘budding crypts’ and a central ‘villus-like’ domain. The main intestinal cell types are shown in green, blue, red and purple. Membranes are yellow and nuclei cyan.