Frizzled (FZD) receptors are key players in a pathway called Wnt that promotes malignant cell growth, making them a promising ...

NA activity was determined in 96-well white U-bottom microplates (Greiner bio-one GmbH, Frickenhausen, Germany) using the CL-based NA-Star assay (NA-Star Influenza Neuraminidase Inhibitor ...

With over 15 years of experience in kinase drug discovery, DiscoverX offers the largest collection of nearly 500 biochemical and cell-based kinase assays. KINOMEscan® technology, our novel kinase ...

Binding affinity was assessed using Fortebio. Human peripheral blood mononuclear cells (PBMCs) were cocultured with molecules to test the antibody-dependent cellular cytotoxicity (ADCC) potency. IFN-α ...

a novel inhibitor of Tyk2. Methods Safety, PK, TE, and PD were assessed in a randomized, double-blind, single and multiple ascending dose study of 108 (83 active: 25 placebo) healthy participants ...