The aromatic rings in guanine's structure make it a relatively stable molecule, but it can still undergo various chemical reactions, such as oxidation, reduction, and methylation. One of the most ...

The majority of DNA methylation occurs at CpG sites, which are cytosines that precede a guanine nucleotide. Traditionally, methylation is examined at a specific CpG site independently of any ...

a Foundation Model for DNA Methylation. Image Credit: Shutterstock AI In a recent pre-print* study posted to the bioRxiv server, a team of researchers introduced the Cytosine-phosphate-Guanine ...

and the amount of guanine is equal to the amount of cytosine in a double-stranded DNA molecule. This 1:1 ratio of A:T and G:C is crucial for maintaining the structure and stability of DNA.

The study employed high-throughput methods such as barcoded bisulfite amplicon sequencing to measure methylation at androgen-sensitive cytosine-phosphate-guanine (CpG) sites, specifically ...