Methylation knocks out gene function; methyl groups placed on CpG islands (relatively rare clusters of cytosine and guanine bases connected by a phosphorylation site) effectively prevent gene ...

The study employed high-throughput methods such as barcoded bisulfite amplicon sequencing to measure methylation at androgen-sensitive cytosine-phosphate-guanine (CpG) sites, specifically ...

Dunn, recently carried out a study exploring how DNA methylation, an epigenetic modification that entails the addition of a methyl group to the DNA, contributes to the well-documented relationship ...

Serum mucin 5AC (MUC5AC) as a predictor of outcomes and microscopic distant metastasis in pancreatic ductal adenocarcinoma (PDA). This is an ASCO Meeting Abstract from the 2025 ASCO Gastrointestinal ...

One in every 10 people worldwide is impacted by a rare genetic disease but about 50% of them remain undiagnosed despite rapid ...

The G-quadruplex (G4) structure is formed specifically by DNA or RNA molecules and represents a planar structure formed by four guanine bases linked via hydrogen bonds. (1,2) This structure is ...

Introduction: DNA methylation inhibitors have been approved for the prevention of Acute Myeloid Leukemia (AML), and their safety profile is not fully characterized. This study was aimed at evaluating ...

Ph.D. student Shloka Negi analyzes long-read sequencing data in the UC Santa Cruz Computational Genomics lab.

Center for Biopharmaceuticals and Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Jagtvej 160, DK-2100, Copenhagen, Denmark ...

One in every 10 people worldwide is impacted by a rare genetic disease but about 50% of them remain undiagnosed despite rapid ...