cell communication and transcriptional regulation, consistent with the expected role of Foxp3 in Treg differentiation. Thus, the role of Foxp3 as a forkhead nuclear transcription factor regulating ...

调节性T细胞是维持机体免疫稳态的CD4+ T细胞亚群，也是肿瘤微环境中免疫抑制屏障的主要构成细胞。因此，特异性地调控肿瘤微环境的Treg细胞使其功能与稳定性发生改变，将能够促进肿瘤杀伤反应的发生。

Quell has developed a platform that works by ensuring the sustained expression of forkhead box P3 (FOXP3) in Treg cells. This protein is a crucial regulator of Treg cell gene expression and is ...

One cluster displayed a Treg phenotype, expressing markers such as FOXP3 and IL2RA, and exhibited suppressive characteristics. Another cluster contained cytotoxic cells expressing EOMES and ...

We are particularly interested in understanding the role of the forkhead family transcription factor Foxp3 in establishing and maintaining immune homeostasis; and in the plasticity of regulatory T ...