Ovarian tumors are infiltrated by both effector (CD4+CD25-) T cells and by an excess of TREG cells (CD4+CD25+). These TREG cells impede the function of the effectors in combating the tumor.

Previous studies on regulatory T-cell (Treg) reconstitution after allogeneic hematopoietic SCT (HSCT) have suggested that, within the GVHD process, imbalance between effector T cells and Tregs may ...

known as tumor-infiltrating Tregs (TIL-Tregs), allow cancer to evade immune attacks by suppressing the activity of effector T ...

Immune cells called regulatory T cells have long been known for their role in countering inflammation. In the setting of ...

The results highlight an important physiological function of PGAM in the differentiation and suppressive activity of Treg cells by regulating serine synthesis. This role is proposed to intersect with ...

Researchers identify a pathogenic subset of CD8+ memory T-cells that promote airway tissue inflammation and recurrent respiratory diseases.

Early data shows potent and selective CD8+ T cell activation without substantial changes to Treg and NK cell numbers ... specifically targeted to CD8+ effector T cells, is currently in Phase ...

Early data shows potent and selective CD8+ T cell activation without substantial changes to Treg and NK cell numbers ... specifically targeted to CD8+ effector T cells, is currently in Phase ...