Previous studies on regulatory T-cell (Treg) reconstitution after allogeneic hematopoietic SCT (HSCT) have suggested that, within the GVHD process, imbalance between effector T cells and Tregs may ...

Ovarian tumors are infiltrated by both effector (CD4+CD25-) T cells and by an excess of TREG cells (CD4+CD25+). These TREG cells impede the function of the effectors in combating the tumor.

known as tumor-infiltrating Tregs (TIL-Tregs), allow cancer to evade immune attacks by suppressing the activity of effector T ...

regulatory T cells, effector T cells, and memory subsets, as well as unique subsets like γδ T cells, MAIT cells, and NKT cells. The research emphasizes the vital roles these subsets play in ...

Early data shows potent and selective CD8+ T cell activation without substantial changes to Treg and NK cell numbers ... specifically targeted to CD8+ effector T cells, is currently in Phase ...