Autophagy is a process by which cellular material is degraded by lysosomes or vacuoles and recycled. Several autophagy pathways operate within a cell, including macroautophagy, microautophagy and ...

In 2000, it was suggested to me that “Autophagy will be the wave of the future; it will become the new apoptosis.” Few people would have agreed at the time, but this statement turned out to be ...

This study presents a valuable finding on the alterations in the autophagic-lysosomal pathway in a Huntington's disease model. The evidence supporting the claims of the authors is solid. However, the ...

Of the many factors that contribute to podocytopathies, the abnormal regulation of autophagy, such insufficient or excessive autophagy levels, have been proposed to play a significant role in the ...

1Cellular Degradation Biology Center, College of Medicine, Seoul National University, Seoul, Republic of Korea. 2Department of Biomedical Sciences, College of Medicine, Seoul National University, ...

2015). Moreover, miR-23B has been identified as an effective autophagy inhibitor. By targeting the 3′UTR of autophagy-related gene ATG12, it reduces autophagy activity, thereby enhancing ...

Department of Radiology, Nanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210008, China ...

HCQ and chloroquine have a recognised role as DMARDs in the treatment of RA ... This leads to an acquired lysosomal storage disorder due to the inhibition of constitutive autophagy present in normal ...

Autophagy counterbalances cellular stress associated with oncogenic KRAS activation, as do specific metabolic and reactive oxygen species detoxifying adaptions that represent acquired vulnerabilities.