Metastasis is a multistage process that requires cancer cells to escape from the primary tumour, survive in the circulation, seed at distant sites and grow. Each of these processes involves rate ...

It is evident from the data presented in this Review that primary tumours and their metastatic off-shoots are complex ecologies consisting of numerous cell types. Many of these are derived from ...

Junctional adhesion molecule-A (JAM-A), expressed on the surface of myeloid cells, is required for extravasation at sites of inflammation and may also modulate myeloid cell activation. Infiltration of ...

Of interest is the delineation of two macrophage subtypes: Anti-mac cells (CD45+CD11b+CD86+) and Pro-mac cells (CD45+CD11b+ARG+), with the proportion of Pro-mac/pro-tumorigenic cells significantly ...

and Ly6G (clone 1A8), all conjugated with phycoerythrin (PE)) and antibodies directed against CD45.2 (PerCP/Cy5.5-conjugated, clone 104, 1:300); CD11b (APC/Cy7-conjugated, clone M1/70); F4/80 ...