CD4+ T cells were cultured as described above (3 ug/mL anti-CD3, 3 ug/mL anti-CD28, 10 ng/mL recombinant murine IL-2) with varying ratios of Treg:Teffector cells. Divisions were counted by measuring ...

在一项新的研究中，来自南卡罗来纳医科大学霍林斯癌症中心的研究人员揭示了如何设计嵌合抗原受体（chimeric antigen receptor, CAR）Treg细胞的新规则。这一突破可能为对抗1型糖尿病等自身免疫性疾病提供更有效的工具。

and both Foxp3+ Tregs and type I regulatory T cells (Tr1) are dysfunctional. MS is a multifactorial disease and vitamin D deficiency is associated with disease. Herein, we examined the impact of ...

Despite an increasing repertoire of therapeutic targets, a significant proportion of patients suffer chronic morbidity. Studies in mice and humans have highlighted the critical role of regulatory T ...

Introduction: T regulatory cells (Tregs) inversely correlate with disease progression in Amyotrophic Lateral Sclerosis (ALS) and fast-progressing ALS patients have been reported to exhibit ...

Expert Rev Clin Immunol. 2012;8(1):73-80. According to the UN population division, by 2035 one in five people are expected to be 65 years of age or older. The improved life-spans of elderly ...

Harvard Medical School research reveals highly specialized regulatory T cells that curb inflammation and act as gatekeepers to protect the inner regions of the brain. The work, which was done in mice, ...

The following is a summary of “Role of T cell metabolism in brain tumor development: a genetic and metabolic approach,” ...