Preclinical studies using transgenic mice expressing human CD19 have shown that pre-B cells and their malignant counterparts, as well as pre-existing antibody-producing and autoantibody-producing ...

At the end of the incubation the cells were spun, supernatant aspirated, and the cells were stained with rat anti-mouse CD11b (Pacific blue), CD5 (PE), CD19 (APC), and incubated for 30 min on ice. The ...

干细胞被称为医学界的“万用细胞”，因其具备自我更新和分化为多种细胞类型的能力，可用于修复和再生受损组织。它们在现代医学中发挥着重要作用，为疾病治疗和人类健康带来了新希望。间充质干细胞（MSC）因其来源丰富、安全性高，且具备免疫调节和 ...

Targeted therapy approaches are increasingly implemented in cancer therapy regimens, often complementing conventional treatments (e.g., chemotherapy, radiation). Among these novel strategies, targeted ...

4.2 Current status of CD19-CAR-T cell therapy for systemic sclerosis and autoimmune disease Existing research has preliminarily confirmed the feasibility and potential benefits of CD19 CAR-T cell ...

The cell nuclei were stained with hematoxylin for 3 min at 25°C. For immunofluorescence, after being incubated with primary antibodies (anti-cleaved-Caspase-3, anti-phospho-MLKL (S345), anti-F4/80, ...

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This case of a successful treatment of multi-refractory primary immune thrombocytopenia adds to the growing body of evidence supporting the use of CD19 CAR T-cell therapy in B cell-driven autoimmune ...

Bacterial outer membrane vesicles (OMVs) have emerged as promising vehicles for anticancer drug delivery due to their inherent tumor tropism, immune-stimulatory properties, and potential for ...