STV-independent approach illustrates the method proposed by Najat Bdeir et al. (2019). In this approach, DI-244 particles of IAV were generated solely from the plasmids, using 293T and MDCK cell lines ...

This study provides important insights into the regulation of type-I interferon signaling and anti-tumor immunity, demonstrating that ORMDL3 promotes RIG-I degradation to suppress immune responses.

利用原代大鼠海马神经元、SH-SY5Y 细胞和 HEK-293T 细胞，验证 SCFKDM2A E3 连接酶复合物对核 β -catenin 的靶向作用及 KDM2A 的功能。接着，在 tGCI 大鼠模型中，研究 HPC 对 SCFKDM2A 复合物、核 β -catenin K48-Ub 以及 USP22 表达和定位的影响。通过给予 siKDM2A、daminozide、AAV-USP22 ...

Yet many more applications await. One of the most actively investigated gene transfer vehicles and emerging platforms is that of adeno-associated virus (AAV). Simply put, AAV consists of a protein ...

PDE2 (phosphodiesterase 2) is upregulated in human heart failure. Cardiac PDE2‐transgenic mice are protected against contractile dysfunction and arrhythmias in heart failure but whether an acute ...

The unique combination of small size, translucency, and powerful genetic tools makes larval zebrafish a uniquely useful vertebrate system to investigate normal and pathological brain structure and ...

The journey to develop an upstream bioprocess is complex, involving process development, optimization and scale-up. Hence, it’s important to choose the right equipment to accelerate this journey while ...

Chromatin-associated RNAs (caRNAs) form a relatively poorly recognized layer of the epigenome. The caRNAs reported to date are transcribed from the nuclear genome. Here, leveraging a recently ...