For each structural strain of tau fibrils, they identified amino acids without which the strain cannot form its signature ...

The X contains more genes related to brain function than does any other chromosome. “The X chromosome may be a treasure trove of genes that influence cognition, and these could be therapeutic targets, ...

The National Alzheimer’s Coordinating Center unites the collections of the neuropathology cores at 27 NIA-funded AD Research Centers into a single database. It contains records on 13,000 brains, 3,000 ...

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SORL1 knockout, knockin, and transgenic mice are now in the Research Models database. The database will be updated as more models become available.

Unknown. Multiple in silico algorithms yielded conflicting results.

The center unites the collections of the neuropathology cores at 27 NIA-funded AD Research Centers into a single database. It contains records on 13,000 brains, 3,000 of them with extensive clinical ...

Unknown; predicted pathogenic in silico (CADD>20).

Early onset familial Alzheimer disease (eFAD) is hereditary and marked by Alzheimer disease symptoms that appear at an unusually early age. Symptoms can start in a person's thirties, forties, and ...

Missense mutations that derail SORL1 trafficking cause AD. Other variants shift AD risk in East Asians and Europeans. SORL1 dysfunction messes with endosomes in neurons, and with lysosomes in ...

Lactylation, a recently identified post-translational modification, has emerged as important for immune regulation, tissue repair, cancer cell metabolism, and now, potentially, Alzheimer’s disease. In ...

The center accepts donations from residents of a specified geographical area who have longitudinal and/or clinical medical records. Phenotypes are collected for Alzheimer's disease, family history of ...