Tau is a protein that builds up and moves between nerve cells in the brains of people living with Alzheimer’s disease, causing damage. Professor Mudher is using clever genetic manipulation in fruit ...
For the first time, scientists have developed a drug that works on both major aggregation-promoting "hotspots" of the tau protein in the brain—a key driver of neurodegeneration. The drug ...
They consist of aggregates of abnormally phosphorylated tau proteins that are altered in conformation. Conformational changes in tau proteins are thought to be the earliest neurobiological changes ...
Working with human cells and animal models of tau-driven dementia, the researchers are the first to show that TYK2's modifications to tau contribute to tau-mediated disease. "We found that TYK2 ...
Scientists have developed two new imaging agents that work better than the only currently approved one for detecting tau ...
A comprehensive study of brain scans from more than 600 people has shed new light on the relationship between tau protein and ...
Tau is a microtubule-associated protein encoded by the MAPT gene located on chromosome 17q21. It promotes microtubule assembly and stability and may play a role in establishing and maintaining ...
People with Alzheimer’s have a build-up of two kinds of protein clumps in the brain: amyloid and tau. These seem to start forming in our memory centres, two small curved structures on either ...
Acupuncture treatment on the DU channel has shown therapeutic effects for Alzheimer’s disease (AD), but the underlying mechanisms are not yet clear. The purpose of this study was to comprehensively ...