本研究首次证实了 SERPINI1 在 HCC 中的诊断和预后价值，以及它在促进 HCC 细胞增殖、迁移和侵袭中的生物学功能。SERPINI1 在 HCC 患者血清中的水平显著高于健康对照者，且与肿瘤大小、分期、分化程度、血管侵犯和淋巴结转移相关。SERPINI1 与 AFP 联合检测可提高诊断的敏感性和特异性，有望成为 HCC 潜在的诊断和预后生物标志物。

目前，针对肺纤维化的研究和药物开发面临着巨大挑战。虽然已经有多种肺纤维化模型，比如用博来霉素诱导的肺纤维化动物模型，能展现出肺纤维化的主要特征，广泛用于相关研究和药物筛选；还有基于干细胞分化的纤维化肺类器官模型，可以模拟特定的纤维化肺病；以及能自组装的 3D ...

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Hypospadias is a widespread congenital disorder, characterized by an abnormal placement of the urethral opening, impacting as ...

A recent study has uncovered the pivotal role of the transcription factor SOX9 in the development of hypospadias, a common congenital condition that ...

A recent study has uncovered the pivotal role of the transcription factor SOX9 in the development of hypospadias, a common ...