Further functional studies revealed that Th17 cells promote the proliferation, collagen expression, and migration of keloid fibroblasts by secreting IL-17A. Importantly, increased Th17 cells were also ...

This study aims to determine the role of Th17 cells in the development of experimental SS (ESS). Methods The ESS was induced in wildtype and IL-17A knockout (IL-17 KO) C57BL/6 mice immunised with ...

and whether the therapeutic response to anti-TNFα is compromised in patients and mice because of elevated Th17/IL-17 levels. Finally, to assess the efficacy of combined blockade of anti-TNFα and ...

There is conflicting evidence from experimental studies on the relative roles of TNFα, IL-8 and cytokines released by Th1, Th2 and Th17 lymphocytes in UC. This may be further complicated by ...