Tau is a microtubule-associated protein that helps to stabilize the structure of neurons, specifically by supporting ...

This manuscript describes the identification and characterization of 12 specific phosphomimetic mutations in the recombinant full-length human tau protein that trigger tau to form fibrils. This ...

The current human tissue-based study provides convincing evidence correlating hippocampal expressions of RNA guanine-rich G-quadruplexes with aging and with Alzheimer's Disease presence and severity.

Andy Extance charts how research into revolutionary targeted protein degradation therapies is moving from serendipity to ...

The oral herpes virus appears to be linked with Alzheimer’s disease, suggesting that the common infection might play a role in the disease, a new study published in the journal Cell Reports says.

Viruses like Covid and HSV-1 may trigger neurodegenerative diseases by causing protein accumulation in the brain, leading to conditions such as Alzhei ...

People with Alzheimer’s disease (AD) have a build-up of tau proteins in the brain which stick together and become tangled. These ‘tangles’ damage the internal structure of nerve cells affecting how ...

Their new research has also revealed how tau protein may initially protect the brain from the virus but later contributes to brain damage. The findings are published in Cell Reports in an article ...

In addition to diagnostics, the device holds promise for advancing protein research. Proteins perform essential roles in cells, and even slight changes in their structure can affect health. Current ...

1 International Research Center for Environmental Membrane Biology, College of Food Science and Engineering, Foshan University, Foshan, China 2 Foshan ZhiBao Ecological Technology Co. Ltd, Foshan, ...

Additionally, some of the therapeutic antibodies can cause serious side effects. Before I joined the group, the Eisenberg team used tau’s structure to design a six-residue, D-enantiomeric peptide ...