Oncolytic adenoviruses were designed to reach potent intratumoral T-cell activation via expression of bifunctional-T-cell engagers (MATEs). MATEs consist of a CD3 binding domain to bind T cells and a ...

The field of immunology has long recognized the pivotal role of T lymphocytes in the adaptive immune system, particularly in pathogen defense, tumor ...

B-cells produce antibodies to attack bacteria and viruses that enter the body. T cells directly attack foreign invaders and cancer cells and produce chemicals that activate other immune cells.

Background The immune suppression mechanisms in pancreatic ductal adenocarcinoma (PDAC) remain unknown, but preclinical ...

The three-signal model provides an empirical framework for innate instruction of adaptive immunity, but mainly discusses STAT-dependent cytokines in T cell activation and differentiation, while the ...

Copyright: © 2025 Elsevier Ltd. Published by Elsevier Ltd. CAR T-cell therapies have revolutionised treatment of many diseases, but their expense means many patients ...

As noted above, stellate cell activation is the central event in hepatic fibrosis. Activation consists of 2 major phases: (1) initiation (also called apreinflammatory stage) and (2) perpetuation ...

The best T-Mobile cell phone plans give you access to unlimited data each month. But the question you need to answer when you have to pick a T-Mobile plan is which of T-Mobile's several unlimited ...