Single-cell RNAseq analysis in human and murine lungs suggests the presence of two HIGD1B+ pericyte subtypes. Upon hypoxia, type 1 pericytes remain quiescent in the capillary network, while type 2 PCs ...

The immune cells are postulated to exert a pivotal role in the development of fibrotic skin disease. Single-cell RNA sequencing has been used to explore the ... ab184993), rabbit anti-alpha smooth ...

The ECM (extracellular matrix) provides the microenvironmental niche sensed by resident vascular smooth muscle cells (VSMCs ... In all comparisons, there was also upregulation of EV markers, including ...

Unbiased single-cell techniques have been used to characterize homogeneous immune cell populations in health and disease, discover stochastic gene expression changes that drive immune responses, and ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Single cells are typically typed by clustering ...

When stimulated by the autonomic nervous system to contract from the release of hormones or other chemical signals, smooth muscle cells shorten via the movement of actin and myosin myofilaments. The ...

However, there is strong agreement that α-SMA is not an exclusive marker for activated PSC. It is also expressed by myofibroblasts, smooth muscle cells and pericytes in blood vessels as well as ...

"What we discovered is a specific transporter, a protein on the membrane of airway smooth muscle cells, allows cAMP to leak into the blood," said Reynold Panettieri, one of the study's senior ...

Blood vessels are mainly made up of smooth muscle ... More information: Moritz Lehners et al, Single-cell analysis identifies the CNP/GC-B/cGMP axis as marker and regulator of modulated VSMCs ...

"What we discovered is a specific transporter, a protein on the membrane of airway smooth muscle cells, allows cAMP to leak into the blood," said Reynold Panettieri, one of the study's senior authors ...